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Volume 3,Issue 7

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20 July 2025

高脂血症性急性胰腺炎中肠道菌群的作用机制及干预策略的研究进展

晨 张1 思玮 陈2 哲 荆1 景怡 曹1 坤 庄2
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1 延安大学医学院研究生院, 中国
2 西安市中心医院, 中国
© 2025 by the Author. Licensee Art and Design, USA. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

高脂血症性急性胰腺炎(Hyperlipidemic    Acute    Pancreatitis,    HLAP)是一种与脂代谢异常密切相关的重症胰腺疾病,其发病机制复杂且临床预后较差。近年研究表明,肠道菌群失调通过脂代谢紊乱、炎症反应失衡及肠屏障损伤等途径深度参与HLAP的病理进程。本文系统综述了HLAP患者肠道菌群的特征性改变及其与疾病分级的关联,阐述了菌群失调通过胆汁酸代谢重编程、短链脂肪酸耗竭及免疫调节异常加剧胰腺损伤的机制并进一步探讨了靶向肠道菌群的干预策略在动物模型中的潜在疗效。

Keywords
高脂血症性急性胰腺炎
肠道菌群
短链脂肪酸
肠屏障损伤
粪菌移植
References

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