Volume 1,Issue 2
Bibliometric and Visual Analysis of the Clinical Research Progress of the Classic Prescription Danshen Yin
Objective: Conduct a comprehensive bibliometric and visual analysis of the clinical research on the classic prescription Danshen Yin to gain an in-depth understanding of its current status and provide valuable references for its further clinical application and research. Methods: Covering the time span from the establishment of the database to September 10, 2024, and utilizing six major database platforms such as CNKI and SinoMed. Retrieval was performed with “Danshen Yin” and “clinical” as subject terms. The retrieved articles were imported into Endnote for manual screening. Subsequently, for the screened articles, data were sorted and statistics were conducted through Excel 2023 based on classification criteria including literature source, publication time, research type, application scope, and combination application. Visual analysis of keywords was carried out using VOSviewer and Citespace software. Results: After screening, a total of 444 articles were included for analysis. Regarding publication time, there is an upward trend. The number of research articles gradually increased after 2008, reaching a peak in 2018 and 2019. In terms of literature sources, it includes journal papers and dissertations. Journal articles account for 90.1%, while theses account for 9.9%. Among them, the proportion of Peking University Core Journals is 7.2%. In terms of research type, randomized controlled studies are the most numerous, accounting for 68.0%. In terms of application scope, “coronary heart disease” is the most common, followed by “gastritis”. In terms of combination application, the prescription most frequently combined with Danshen Yin is Gualou-Xiebai-Banxia Decoction. Additionally, in the co-occurrence analysis of keywords, “coronary heart disease”, “Angina pectoris,” “chronic atrophic gastritis,” “modified Danshen Yin,” “Gualou-Xiebai-Banxia Decoction,” and “promoting blood circulation and removing blood stasis” appear with relatively high frequencies. The time-overlay and salient analysis of keywords indicate that the research focus is gradually shifting from gastric diseases to cardiac diseases. Conclusion: The clinical application of Danshen Yin has drawn extensive attention from modern physicians and shows a high degree of compatibility with clinical practice. However, the quality of clinical research needs to be improved. More reasonable clinical trial protocols should be designed, and large-sample studies need to be conducted.
[1] Chen X, 2020, Collection of Prescriptions in Popular Use. Fujian Science and Technology Press, Fujian.
[2] Li J, Liu D, Wang C, 2021, Encyclopedia of Chinese Medicine: Pharmacology of Traditional Chinese Medicine. China Union Medical University Press, Beijing, 2021.02.
[3] Chen X, 1984, Treatment of 52 Cases of Stomachache with Danjin Erxiang Decoction. Hubei Journal of Traditional Chinese Medicine, 1984(3): 14.
[4] Liu J, 2019, Clinical Research Methods in Evidence-Based Traditional Chinese Medicine. People’s Health Publishing House, Beijing.
[5] Schulz K, Altman D, Moher D, et al., 2010, CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials. BMC Med, 8: 18.
[6] Yang Y, 2024, Clinical Observation on the Treatment of Chronic Heart Failure (Qi Deficiency and Blood Stasis Syndrome) with Modified Buzhong Yiqi Decoction Combined with Danshen Decoction, thesis, Heilongjiang University of Chinese Medicine.
[7] Xiong L, Yao D, 2021, Observation on the Therapeutic Effect of Danshen Yin Combined with Liu Junzi Decoction Plus Chemotherapy in the Treatment of Gastric Cancer with Qi Deficiency and Blood Stasis Syndrome. Big Health, 2021(21): 188–190.
[8] Liu Q, Xu X, 2023, Observation on the Clinical Efficacy of Modified Danshen Yin Combined with Xuefu Zhuyu Decoction Plus Western Medicine in the Treatment of Patients with Qi Stagnation and Blood Stasis Type Coronary Heart Disease and Heart Failure. Cardiovascular Disease Prevention and Control Knowledge, 13(34): 6–11.
[9] Zhang J, 2019, Clinical Observation on the Therapeutic Effect of Modified Danshen Yin in the Treatment of Dysphagia after Surgery for Middle and Lower Esophageal Cancer (Qi Stagnation and Blood Stasis Syndrome), thesis, Chengdu University of Traditional Chinese Medicine.
[10] Xu Q, 2023, Clinical Observation on the Therapeutic Effect of Yiguanjian Combined with Modified Danshen Yin in the Treatment of Paroxysmal Atrial Fibrillation (Yin Deficiency and Blood Stasis Syndrome), thesis, Hubei University of Chinese Medicine.
[11] Zhu B, 1992, Clinical Observation on the Treatment of 34 Cases of Atrophic Gastritis with Self-made Yuzhu Danshen Yin. Tianjin Journal of Traditional Chinese Medicine, 1992(5): 19.
[12] Liao J, Ren K, Zhang X, et al., 2022, Clinical Observation on the Treatment of Yang Deficiency and Blood Stasis Type Chronic Heart Failure Patients with Metabolic Syndrome by Shipi Danshen Yin. China Prescription Drug, 20(7): 123–125.
[13] Wang J, 2007, Treatment of 60 Cases of Diabetic Coronary Heart Disease with Integrated Traditional Chinese and Western Medicine. Forum on Traditional Chinese Medicine, 2007(4): 37.
[14] Cheng Y, 2016, Observation on the Therapeutic Effect of Xuefu Zhuyu Decoction Combined with Danshen Yin in the Treatment of Simple Diabetic Retinopathy. Modern Journal of Integrated Traditional Chinese and Western Medicine, 25(3): 281–283.
[15] Liao L, 2022, Treatment of Type 2 Diabetic Gastroparesis with Spleen Deficiency, Phlegm, and Blood Stasis Syndrome by Xiangsu Liujunzi Decoction Combined with Danshen Yin. Diabetes New World, 25(6): 95–98.
[16] Mao X, 1992, Clinical Observation on the Treatment of 30 Cases of Hyperlipidemia with Modified Danshen Yin. Xinjiang Journal of Traditional Chinese Medicine, 1992(2): 23.
[17] Liang Y, 2019, Clinical Observation on the Treatment of Hyperlipidemia (Phlegm and Blood Stasis Syndrome) with Wendan Decoction Combined with Danshen Yin, thesis, Hunan University of Chinese Medicine.
[18] Li X, Xu Y, Sun Y, 2018, Therapeutic Effect of Danshen Yin as an Adjuvant to Intravesical Chemotherapy in the Treatment of Qi and Yin Deficiency Type Bladder Cancer and Its Impact on Immune Function and Gastrointestinal Side Effects. Modern Journal of Integrated Traditional Chinese and Western Medicine, 27(33): 3737–3740.
[19] Tang J, 2020, Analysis of the Therapeutic Effect of Applying Gualou Xiebai Banxia Decoction Combined with Danshen Yin in the Treatment of Angina Pectoris. Journal of Cardiovascular Surgery (Electronic Edition), 9(1): 96.
[20] Tian P, 2021, Clinical Study on the Treatment of Unstable Angina Pectoris with Gualou Xiebai Banxia Decoction Combined with Danshen Yin, thesis, Beijing University of Chinese Medicine.
[21] Chen J, 1996, Therapeutic Effect of 42 Cases of Coronary Heart Disease and Angina Pectoris Treated with Danshen Yin Combined with Shengmai San. Hunan Journal of Traditional Chinese Medicine and Herbology, 1996(2): 18–19.
[22] Zhang W, 2019, Clinical Study on the Treatment of Qi and Yin Deficiency Type Stable Angina Pectoris with Modified Shengmai San Combined with Danshen Yin. New Journal of Traditional Chinese Medicine, 51(7): 103–105.
[23] Zhang Y, 2018, Observation on the Therapeutic Effect of Xuefu Zhuyu Decoction Combined with Danshen Yin in the Treatment of Heart Blood Stasis Type Coronary Heart Disease. Modern Healthcare (Second Half Monthly Edition), 2018(3): 93–94.
[24] Zhang L, 2019, Analysis of the Therapeutic Effect of Xuefu Zhuyu Decoction Combined with Danshen Yin in the Treatment of Heart Blood Stasis Type Coronary Heart Disease. Dietary Healthcare, 6(1): 109–110.
[25] Li L, 2023, Clinical Observation on the Therapeutic Effect of Auricular Acupoint Pressure Combined with Traditional Chinese Medicine in the Treatment of Gastroesophageal Reflux Disease. Guide of China Medicine, 21(4): 108–111.
[26] Lu Y, Zhang L, Fu D, et al., 2023, Effects of Modified Danshen Yin Combined with Deoxyribonucleotide Sodium Injection on Cardiac Function and Oxidative Stress in Adults with Viral Myocarditis of Qi Stagnation and Blood Stasis Syndrome. Hebei Journal of Traditional Chinese Medicine, 45(7): 1111–1113 + 1119.