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20 May 2025

丹酚酸A抗炎症作用的机制研究

起文 龙1 清霞 黄1 波 金1
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1 浙江中医院大学生命科学学院, 中国
MRP 2025 , 3(5), 53–56; https://doi.org/10.61369/MRP.2025050027
© 2025 by the Author. Licensee Art and Design, USA. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

目的:通过网络药理学和分子对接技术,探讨丹酚酸A(Salvianolic    acid    A,SalA)抗炎作用的靶点及其作用机制。方法:以多个数据库预测SalA的作用靶点以及炎症相关的靶点,并取交集,得到SalA治疗炎症的关键靶点;用STRING数据库进行分析,并进行基因本体论(Gene    Ontology,GO)功能及京都基因与基因组百科全书(Kyoto   Encyclopedia    of    Genes    and    Genomes,KEGG)通路富集分析。通过AutoDock    Vina进行分子对接模拟验证。结果:共获得SalA作用预测靶点578个、炎症靶点2022个,药物、疾病共同交集的靶点有140个,暗示SalA可能通过凋亡通路、焦亡通路等发挥抗炎作用。分子对接验证核心靶点与SalA之间亲和力较强。结论:SalA可能通过多个炎症蛋白结合,多靶点调控多通路发挥抗炎作用。

Keywords
网络药理学
丹酚酸A
抗炎
分子对接
References

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