This article is about the coinfection of 2019-nCoV and influenza A virus, secondary mycoplasma pneumonia infection. The patient has the primary disease of kidney stones, which belongs to the high-risk group. By the treatment of Traditional Chinese Medicine (TCM) and Western Medicine, the result showed that although Western Medicine can effectively remove influenza A virus and Mycoplasma pneumonia, it is not effective against 2019-nCoV. Finally, the treatment of TCM based on syndrome differentiation was used to effectively remove the 2019-nCoV, effectively prevent the occurrence of cytokine storms, and successfully cured this case of coronavirus disease. Simultaneously, to explore the pathomechanism of TCM and Western Medicine, to analyze the susceptible constitution, “preventing a change of disease”, to prevent the transition to critical and critical illness, and to reduce mortality. It is of great significance to promote the treatment of TCM and Western Medicine to defeat the coronavirus disease in the whole country in the future.